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Medications

Anyone else on Rybelsus feeling it wear off today?

Started by LaurenCross · · 29 replies · 167 views
#1

Halfway through my day and the appetite suppression feels noticeably weaker than usual, like the pill just is not hitting the same this time. Down 29 lbs on it so far, so I know it works for me, but days like this make me wonder if timing with food matters more than I thought. Does anyone else on Rybelsus get these random dips in effectiveness?

#2

I get those dips too, usually days where nothing sounds good at all and then one where the food noise creeps back in. Took a while for me to notice my morning routine made a difference, so if I skipped my usual empty stomach wait, I could kind of tell later. At 23 lbs down I figure an off day here and there is just noise, not the med quitting.

#3

On the shot version I get those random off days too and they always bounce back by the next dose, so I would not panic over one afternoon. Only 8 lbs down for me so you are way ahead of me, but from what I can tell the med is still in your system doing its thing even when the quiet day feels loud.

#4

29 lbs down on the pill is solid, so one weird day probably means nothing. I noticed the same thing with my routine too — if I rushed my morning or ate too soon, the afternoon felt way louder food-wise. On days it dips now I just ride it out and it usually snaps back by the next one.

#5

45 lbs down on the shot here and I still get random loud afternoons like that, always gone by the next day. The empty stomach timing thing others mentioned was huge for me too on the pill before I switched, so a rushed morning could easily explain it. One off day after 29 lbs is just noise.

#6

Down 53 lbs here and I still get the occasional loud afternoon where nothing seems to be working, then the next day it's quiet again. My rushed mornings with coffee too fast were usually the culprit back when I was on the pill, so that timing theory of yours tracks with what I saw. One soft day after 29 lbs is just noise.

#7

Those rushed mornings were my downfall on the pill too, especially anything with coffee right after taking it. Early on I barely had any suppression to lose, but even at 4 lbs down I noticed the difference between a calm breakfast and a chaotic one. One afternoon of quiet appetite control after 29 lbs seems like a fluke to me.

#8

On the shot myself so can't speak to pill timing, but my loud days on Ozempic at 1mg pretty much always line up with chaotic mornings, and they've never lasted past the next one. After 29 lbs, one soft afternoon feels like a fluke, not a trend.

#9

Only 13 lbs in on Rybelsus myself, but I've already noticed my hungriest afternoons follow mornings where I scarfed breakfast and coffee right after the pill. The days I actually sit and wait a bit before eating, suppression holds way better. I'd log what tomorrow morning looks like before assuming anything changed.

#10

17 lbs in on the shot here and same pattern - my rough afternoons line up with mornings I ate too soon after taking it. With 29 gone you've clearly got plenty of proof it's still working for you, so I'd track a few mornings before worrying.

#11

Down over 50 on the shot, and my off days still trace back to rushed mornings more often than anything else. No pill experience, but second the suggestion to log a few mornings before assuming the Rybelsus stopped working. One wobbly afternoon after 29 lbs is way more likely a blip than a trend.

#12

On tirzepatide so no pill experience, but my hungriest days on 5mg almost always trace back to a rushed, chaotic morning too. With 29 lbs down, one wobbly afternoon sounds like a fluke to me, but the food timing theory the last poster mentioned seems worth logging for a few days.

#13

Lost 39 lbs on the shot and my weak afternoons almost always follow mornings where I ate or drank coffee way too close to taking it. With the pill that timing window is supposedly even tighter, so I'd note what you had around your dose for a week before assuming anything. One off day after 29 lbs down is just noise to me.

#14

Only 14 lbs in on my end but even I've noticed my crummy afternoons cluster around mornings I grabbed coffee right after the pill. Worth jotting down your food and drink timing for a week - I bet the pattern shows up fast given how well it's worked for you so far.

#15

Rybelsus user here too, and the afternoon fade hits me most on day five or six of the week. Moving most of my protein to lunch has been the one tweak that smoothed that out. Slow climbs are where it's at, I sat at my dose way longer than the schedule suggested and no regrets.

#16

Early days for me at 3 lbs down but I already noticed the same thing - my one foggy afternoon came the morning I chugged coffee right after the pill. Waiting a bit with an empty stomach seems to make a difference for me, so that might be worth checking against your routine.

#17

At 22 lbs down I still get the occasional weak afternoon, and mine line up with mornings I ate too soon after taking it. Keeping the pill fast and plain on an empty stomach has made those dips way rarer for me. Congrats on the 29, that is solid progress on an oral.

#18

Same pattern here, my soft afternoons almost always trace back to eating earlier than usual after the pill. Since I started taking it first thing with nothing but water and waiting a while before breakfast, those dips got pretty rare. At 29 lbs down, one off day is just noise.

#19

53 lbs down on Rybelsus here and I still get the odd soft afternoon, usually when I was rushed and ate breakfast earlier than normal. I've landed on taking it right when I wake up with just water and not touching food for a good while, and those dips mostly stopped. At 29 lbs you're clearly doing something right, so I wouldn't read too much into one off day.

#20

18 lbs in on Rybelsus and my only soft afternoons have been the days I grabbed breakfast too early after the pill, so yeah, the timing thing seems real from my end too. One off day at 29 down is nothing to sweat.

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