Tirzepatide and muscle mass — what the research says

Curious whether anyone has actually seen the lean mass difference show up on a scan rather than just in the trial averages. My own DEXA is still sitting unbooked months later.

tbh curious whether anyone on zepbound has seen their bar numbers actually drop, since that seems like the real test. My lifts held fine through the first stretch but i'm only now noticing my pressing feels heavier some weeks

Mine slid a little on the big lifts before I added more protein

I switched from sema to tirzepatide partway through and honestly my own body comp readings didn't shift much either way. The lean mass difference in the trials reads like a rounding error next to just keeping my protein up.

Curious whether anyone here actually did a dexa scan before and after rather than going off how the lifts felt, since that seems like the only way to really see it

curious whether anyone here actually got a DEXA scan before and after rather than going off how the lifts felt. That's the comparison I keep wanting to see.

I haven't done a DEXA or anything, so my only read on it is the gym

honestly, i did a DEXA at the start too and the lean mass number surprised me, so now I lift twice a week mostly to keep an eye on it. Curious whether you plan to rescan at a set point or just whenever.

I did an inbody scan early on too and the lean mass number barely budged, which surprised me since i was barely eating. My own take is that any of these meds will cost you some muscle if you drop weight fast and don't keep protein and resistance work up, so the drug comparison matters less than what you do alongside it

I did a repeat DEXA around month five and the lean mass drop was smaller than I expected, though I was lifting the whole time. Curious whether the folks getting inbody scans are also tracking their protein.

The protein angle is what I keep coming back to. How much are you actually hitting a day?

tbh i did a repeat DEXA about six months in and the lean mass drop was smaller than I expected, though I have nothing to compare it against since I never scanned before starting. The protein thing the others mentioned has been most of my approach too.

Did you do a repeat scan after switching or is that just how it felt? I keep putting off a second one because the first was already depressing enough.

I did a dexa at month four and honestly the lean loss number was smaller than i braced for. What i cant tell you is whether thats the drug or just me finally eating enough protein

I've been tracking body comp the low tech way with a tape measure and my lifts, since DEXA around Spokane was a hassle to book. The trial data on lean mass is interesting but I trust feeling stronger week to week more than any single scan.

honestly dEXA is a pain to schedule here too, so I just log my lifts.

My deadlift actually crept up a little after the first few months, which surprised me since I assumed everything would just get weaker. Curious whether you're lifting already or still figuring out where to start with it.

I've been doing DEXA scans every few months since starting and the lean mass drop was real but smaller than I expected, though I also started lifting again around the same time so who knows what's doing what

Body comp scans are the only thing that settled it for me. Dexa showed my lean mass basically flat while fat dropped, so the med itself wasn't eating my muscle, the couch was

I've been lifting throughout and my strength has held steady, so anecdotally I haven't seen the lean mass drop the studies warn about. The DEXA comparisons I read were small and short, which makes me skeptical the tirzepatide edge is as clean as headlines suggest.