semaglutide and appetite fully returning mid-week

Anyone else notice the food noise creeping back by day 5 or 6 before the next shot? I am down 53 lbs but lately I get genuinely hungry again mid-week even though the dose has not changed. Curious if this happens to others or if it is just my body adapting after so many months on the medication.

Day 5 hunger shows up for me too even though I'm only a couple months in and just down 3 lbs, so you're not alone in it. I've started front-loading my protein earlier in the week so the late-week noise doesn't hit as hard. Considering it hit you after 53 lbs lost, I'd guess it's just your body recalibrating rather than anything going wrong.

Hit the same wall around day 5 or 6 on my way down 29 lbs, usually right when I'm standing in front of the pantry. I stopped fighting it and just keep easy protein stuff prepped for the end of the week, and the noise quiets down again within a day of my next shot. After 53 lbs your body may just be renegotiating, doesn't sound like anything's broken.

Same thing happened to me around the 7 month mark on the pill version, day 6 was always the loudest. I just roll with it now and plan higher protein meals for the back half of the week, appetite still drops off again right after I take it. 53 lbs is no joke, your body probably just needs a bit of time to settle into the new normal.

Down 56 myself and the pantry haunting around day 6 is real. I just keep my fridge stocked like the others said and let the next shot do its thing, hunger fades again by the day after. At this point in the loss I figure some hunger is just the new normal, not a malfunction.

Same window for me, hunger ramps up around day 5 and I'm only down about 20 lbs, so it's clearly not tied to how far along you are. I just plan bigger meals toward the end of the week and stop stressing when the noise shows up, since it always resets the day after my shot.

Has your sleep changed at all since starting? Titrating slowly is so underrated, no rush to climb.

Down 60ish and mine kicks in around day 5 too, always right after dinner when I'm most tempted to graze. I started front-loading protein at breakfast that late-week stretch and it takes the edge off enough to get by. It resets the day after the shot for me like clockwork, so I stopped reading it as anything going wrong.

I stayed on the starter dose an extra month and it was the right call. Hit goal weight this morning, still in shock.

Down about 45 myself and same pattern, days 5-6 get loud again. I stopped seeing it as the med failing once I noticed it resets right after the next shot, it's just the weekly cycle. Extra protein earlier in the day on those late-week stretches helps me ride it out.

Month 3 was also my turning point on Rybelsus — before that it was patchy, some days barely felt anything, then suddenly the food noise mostly stopped and stayed that way. If you're seeing even occasional good days, you're likely right on track.

Same here around day 5-6, down 32 lbs and the hunger definitely comes back before my next shot. I just plan bigger meals those days and it resets fine after injecting. After 50+ lbs lost your body probably just tolerates it differently now, doesn't mean it stopped working.

Down 53 myself on Rybelsus and the late-week hunger hits me too, though with a daily pill mine tends to build more gradually than the day 5-6 spike you're describing. I've noticed the same thing about my body just handling it differently now that the weight is off — eating more early in the day on the rough days keeps me from white-knuckling it.

Peppermint tea settled my stomach on the worst nights. Rooting for you.

Day 5 or 6 used to hit me the same way before I switched to my current dose — down 46 lbs on Wegovy and the hunger creeping back late in the week was wild the first time it happened. I started front-loading protein at breakfast those days and it made the waiting way easier. Seems like a pretty normal adaptation once you've been on it this long.

Only a few pounds down so far so I can't speak to the long-haul part, but the day 5 hunger thing comes up a lot in my group chat with folks a year in, so you're probably not broken. Sounds like eating more earlier in the day on those late-week days is doing a lot of people here some good.

53 lbs in and the hunger still showing up late in the week tracks with what a lot of longer-term folks describe. Front-loading protein early in the day has helped me ride out those stretch days even though I'm barely a month in myself. Sounds like adaptation more than anything going wrong.

Same thing hit me on tirzepatide around month five — by day 5 or 6 I'd feel real hunger again even though nothing changed with my shot. I just started planning bigger protein-heavy meals for those late-week days and it got way more manageable. With 53 lbs gone, your body has probably just recalibrated a bit, which sounds like adaptation more than failure.

How long before your labs started reflecting the change? Worth running past your own prescriber first.

Hit the same wall around month six on semaglutide — days 5 and 6 got noticeably hungrier even at the same dose, and it never turned into a regain for me, just louder days to manage. Now at 76 down I basically plan for it: heavier protein those late-week days and it's a non-event. If it ever ramps up fast instead of gradually, that's when I'd loop in my prescriber.