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Medication holiday — did you take a break? How did it go?

Started by EthanPark · May 01, 2026 · 51 replies · 993 views
May 01, 2026 #1
For anyone considering the switch from semaglutide to tirzepatide: I made that switch at month 6 and the difference in appetite suppression is noticeable. I went from thinking about food constantly (even on sema) to genuinely not being interested. The dual GIP/GLP-1 mechanism really does seem to add something.
May 06, 2026 #3
My titration schedule ended up being much slower than the official guide. 0.25mg for 8 weeks, then 0.5mg for 8 more weeks. My doctor is conservative but the results have been steady and the side effects manageable. There's no prize for going faster.
Jun 04, 2026 #10
Just wanted to say, I keep a food + weight log to spot the trends, not the daily noise. I stayed on the starter dose an extra month and it was the right call. Hang in there. Definitely run it by your own prescriber though.
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