Medication holiday — did you take a break? How did it go?

Started by EthanPark · May 01, 2026 · 3 replies · 917 views
May 01, 2026 #1
For anyone considering the switch from semaglutide to tirzepatide: I made that switch at month 6 and the difference in appetite suppression is noticeable. I went from thinking about food constantly (even on sema) to genuinely not being interested. The dual GIP/GLP-1 mechanism really does seem to add something.
May 06, 2026 #2
My titration schedule ended up being much slower than the official guide. 0.25mg for 8 weeks, then 0.5mg for 8 more weeks. My doctor is conservative but the results have been steady and the side effects manageable. There's no prize for going faster.
Jun 04, 2026 #3
Solidarity from someone who's been through the exact same thing. You've got this.
Jun 17, 2026 #4
My doctor kept me at 0.5mg for 10 weeks. Slower titration, fewer side effects — worth it.