Dosing

Microdosing semaglutide — anyone tried splitting doses?

Started by BrianMoore · May 22, 2026 · 44 replies · 435 views
May 22, 2026 #1
For anyone considering the switch from semaglutide to tirzepatide: I made that switch at month 6 and the difference in appetite suppression is noticeable. I went from thinking about food constantly (even on sema) to genuinely not being interested. The dual GIP/GLP-1 mechanism really does seem to add something.
May 28, 2026 #3
Reading this and Has your sleep changed at all since starting. Did your appetite come back at all on the higher dose. Consistency with my injection day mattered more than the exact dose. This community is the best.
Jun 11, 2026 #9
Following along, Found my sweet spot dose and I'm not in a hurry to go higher. What's your current titration schedule looking like. Did the nausea ease up after the first few weeks for you. Rooting for you.
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